Natural WaterAqua Citrulline

Product Made from Health Ingredients in Watermelons.

We succeeded in finding antiglycation effect from watermelon extract showing AGEs production inhibitory activity.

When watermelon extract was fed to rats, a decrease in triglycerides and leptin a cytokine secreted by adipocytes was observed,
and the extract was found to be effective in suppressing obesity.
"Aqua Citrulline" prepared using watermelon extract,
when administered to dogs was confirmed to be useful in significantly reducing the serum leptin level
aditionally suppressing the formation of struvite crystals (magnesium ammonium phosphate crystals)
and calcium oxalate crystals in urine that causes urinary tract calculi.

Anti-glycation Effect of Watermelon Extract "WS-A"

Antiglycation action

Glycation is a biological reaction in which excess sugar combines with proteins and fats in our body causing cellular degradation.
During this process, substances associated with aging called AGEs (Advanced Glycation End products) are produced.

AGEs increase when diabetes mellitus is developed and is also associated with arteriosclerosis and Alzheimer's.
If collagen in the skin is converted to AGEs, the skin becomes hard, inelastic, and turns yellow.
Foodstuffs with antiglycation effect that suppress glycation are in demand.

Antiglycation effect that suppresses production of AGEs was discovered in watermelon extract

On adding watermelon extract (WS-A) to a reaction solution prepared by adding glucose to Human Serum Albumin (HSA) to produce AGEs, production of 3DG involved in the production of fluorescent AGEs was found to be inhibited suppressing glycation.

Even when compared to aminoguanidine that has a strong antiglycation effect, watermelon extract exhibited a relatively stronger antiglycation effect, actively suppressed the production of 3DG, a glycation reaction intermediate that is highly reactive.

Watermelon extract showing the new possibilities of watermelon with a strong antiglycation effect is
expected to become a raw material of health foods.